A copper-catalyzed approach for the synthesis of 1-acyloxy-2,2,6,6-tetramethylpiperidines
through the C–C bond cleavage of cyclic or acyclic ketones was developed. In this
chemistry, a combination of CuCl2·2H2O, 1,10-phenanthroline monohydrate, and aniline was crucial for the formation of the
desired products by the reaction of ketones with TEMPO. This research provides a new
strategy for the further transformation of α-aryl cyclic or acyclic ketones.
Key words
copper catalysis - acyloxypiperidines - C–C bond cleavage - ketones - TEMPO